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(2020)\n) and time-to-event\ngeneralized bayesian optimal interval (TITEgBOIN) (Takeda et\nal. (2022) ) designs. 'TITEgBOIN' can\nconduct tasks: run simulations and get operating\ncharacteristics; determine the dose for the next cohort; select\nmaximum tolerated dose (MTD). 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