Package: bfboinet
Type: Package
Title: Backfill Bayesian Optimal Interval Design Using Efficacy and
        Toxicity
Version: 1.1.0
Authors@R: c(
    person("Jing", "Zhu", email = "zhujing716@gmail.com", role = c("cre","aut")),
    person("Kentaro", "Takeda", email = "kentaro.takeda.statistics@gmail.com", role = "aut"),
    person("Belay Birlie", "Yimer", role = "aut"))
Description: Implements the Backfill Bayesian Optimal Interval Design
        (BF-BOIN-ET), a novel clinical trial methodology for dose
        optimization that simultaneously consider both efficacy and
        toxicity outcome as described in (Takeda et al (2025)
        <doi:10.1002/pst.2470>). The package has been extended to
        include a seamless two-stage phase I/II trial design with
        backfill and joint efficacy and toxicity monitoring as
        described in (Takeda et al (2026) <doi:10.1002/pst.70092>).
License: GPL-3
Encoding: UTF-8
RoxygenNote: 7.3.3
Imports: Iso, copula, dplyr, tidyselect, magrittr, BOP2FE, boinet, BOIN
Config/pak/sysreqs: cmake make libgsl0-dev libicu-dev libuv1-dev
        libxml2-dev libssl-dev libnode-dev zlib1g-dev
Repository: https://jingzhuzhuzhu.r-universe.dev
Date/Publication: 2026-04-28 11:59:22 UTC
RemoteUrl: https://github.com/jingzhuzhuzhu/bfboinet
RemoteRef: HEAD
RemoteSha: a25c12d77295d66fca1f44c821618ca2d9810547
NeedsCompilation: no
Packaged: 2026-10-10 13:14:31 UTC; root
Author: Jing Zhu [cre, aut],
  Kentaro Takeda [aut],
  Belay Birlie Yimer [aut]
Maintainer: Jing Zhu <zhujing716@gmail.com>